What is Modafinil
Modafinil is a new generation smart drug that enhances the function of your brain. It is a prescription medicine that belongs to a class of medicines which are referred to as the “waking drugs”. It is an oral drug which is used to treat narcolepsy. Narcolepsy is a condition that makes a person excessively sleepy during day time. Modafinil chemically contains Diphenylmethylsulfinylacetamide 100 mg or 200 mg. Modafinil is the generic term for medicines sold under the brand names Provigil or Modalert (manufactured by Sun Pharmaceuticals). Modafinil is also used in patients who uses breathing devices for Obstructive Sleep Apnea (OSA) or other therapies to prevent excessive daytime sleepiness. Modafinil is a distinctive medicine which improves your neurological function. It is unique in its properties which selectively targets the sleep centre in the brain unlike other medicines which acts on our central nervous system.
When you take Modafinil as single or multiple oral doses, it gets absorbed by the intestines rapidly and its concentration in the blood plasma reaches the maximum at two to four hours. Thus, the drug gets into action within a few hours of consumption. The dosage of Modafinil is usually between 200 to 600 mg/day. It is metabolized by the liver and within 15 hours it is eliminated through urine. Modafinil has been studied to be a moderately long-lived drug which is well absorbed and metabolized by the body.
Modafinil can be bought online in most of the countries with and without prescription, however you can buy Modafinil in India and an Over the Counter (OTC) medicine without a prescription. Modafinil in UK is prescribed as Provigil. Modafinil is legal to use and is often prescribed by physicians to treat a variety of conditions such as “shift work sleep disorder”. In other non- Asian countries, Modafinil may be a prescription drug. One can buy modafinil in UK or USA with an online prescription. To know how to get a prescription for Modafinil online, click here.
Modafinil is available as tablets that are white to off-white in colour, capsule shaped and uncoated. Each tablet contains Modafinil 100 mg or 200 mg and is divided into two halves by score lines. Apart from the main drug, the tablet also contains ingredients such as Crospovidone (Type A), Crospovidone (Type B), Starch (maize) Pregelatinised, Cellulose Microcrystalline, Povidone K-90, Povidone K-30, Lactose Monohydrate, Silica colloidal anhydrous, Talc and Magnesium Stearate.
Modafinil is available under several brand names and the cost varies among brands. It For those who find Modafinil expensive, some websites offer Modafinil at cheap prices too. The information on where to buy Modafinil is available here. Modafinil is often called as the smart drug as it enhances your brains function, mood and concentration. The researchers of Harvard and Stanford called it the “World’s first safe ‘Smart Drug’”
Although considered to be one of the safest drugs to use, some of the common side effects should be kept in mind when you buy Modafinil. Some of the ingredients in the medicine can cause allergy. If you have any known allergy to any of the ingredients, you must avoid using Modafinil. Other side effects while using Modafinil can be an irregular heartbeat and increase in blood pressure (BP). People with psychological disorders such as depression, anxiety, psychosis or mood disorders should take special care while taking Modafinil. Children aged less than 18 years should not take Modafinil. In exceptional cases, teen agers may be administered Modafinil 100 mg to treat certain mood disorders. Headache, nausea, insomnia, nervousness and respiratory tract infections are the most common and less serious adverse effects of Modafinil.
Some side effects of Modafinil such as suicidal thoughts, change in color/amount of urine passed, chest pain, fast or abnormal heartbeat, muscle/joint pain, severe headache, sensory disturbances and bleeding maybe an indication that you must visit your doctor soon.
Even though it is one of the safest drugs to be taken, just like any other drug in the market, the use of Modafinil may involve some risks. it is best used and found effective when taken as per the recommendations of a physician. Especially in people with other medical conditions, Modafinil should be used in consultation with physician. While Modafinil works well for most individuals, in rare cases, the drug may not be effective in all individuals. If you don’t feel a change in a day or two after you start taking Modafinil, you might want to visit your physician to change the drug or doses.
What are the ways by which Modafinil act?
Modafinil works on the brain. It essentially deals with the sleep center in your brain as it reduces excessive sleepiness and keep you awake and fresh when you use it. It is a neruostimulant that enhances your mood, concentration, focus and alertness. Modafinil is an active drug used to treat a variety of sleep conditions.
Every action in the body especially the ones associated with daily function such as reading, writing, and engaging in work that requires good brain function are regulated by certain chemicals in the body called as neurotransmitters. Dopamine is one of such neurotransmitters that plays important roles in the brain and body in terms of thinking, planning, feeling and rewarding. It is a “feel good” neurotransmitter. Although, the exact mechanism of action of Modafinil is unclear, it has shown to function as a Dopamine receptor agonist. It increases the levels of Dopamine in the brain by reducing the Dopamine outflow from the brain. It has also shown to increase the levels of Serotonin, another key hormone that stabilizes our mood, happiness and feeling of Well- being. Modafinil is a drug with greatly promising potential for several used in general medicine and psychiatry.
When the levels of these hormones are increased, the brain cells are stimulated. This is the prime reason for the pleasant and fresh feeling that Modafinil brings in. When the brain is stimulated, we feel active and happy, this help us avoid the excessive sleepiness thus improving our focus, concentration and alertness.
Modafinil has profound effects on other chemicals in the body such as catecholamines, glutamate, gamma amino-butyric acid, orexin, and histamine systems in the brain. These effects may happen inside or outside the brain with majority of the actions occurring within the brain. Among these, the ‘arousal’ as well as ‘activity- promoting’ effects of Modafinil are found to be due to the activity of catecholamines. Furthermore, Modafinil has been found to elevate the function in various cognitive domains that includes episodic and working memory, attention and executive function.
These effects have been demonstrated in healthy adults in several studies. All of these actions put together makes Modafinil a psychostimulant, that acts differently when compared to other medicines used to treat excessive sleepiness such as Amphetamine. Modafinil also alleviates stress and improves your productivity by keeping you active during the day. The use of Modafinil is greatly encouraged at workplaces today due to its cognitive enhancement potential.
Benefits of taking modafinil.
Having greatly appreciated for its ‘mood-elevating’ and ‘memory- enhancing’ actions, the use of Modafinil has significantly increased over the last decade. Modafinil is now used to treat a large number of problems such as Attention deficit hyperactivity disorder (ADHD), Dementia, Jet lag and excessive sleepiness due to extended working hours. The smart drug is also called as ‘nootropic’, meaning it enhances the mood and cognitive function in humans.
Modafinil 100 mg is used to treat mild disorders whereas doses above 200 mg is recommended for moderate to severe conditions. It is the most commonly used “brain booster”. “Sleepiness” type of disorders has been treated by several drugs, however, Modafinil is considered to be unique and is said to be in a class of its own. What makes Modafinil different is;
Modafinil acts like a stimulant. They are Eugeroic (Wakefulness- promoting agent) but does not make you unrealistically fast or jittery like other stimulant drugs. One of the most common side effects of the smart drugs is that they can cause addition or withdrawal symptoms. Modafinil does not cause addition or show any withdrawal symptoms if discontinued. However, some researchers suggest the probability of addiction or withdrawal symptoms on prolonged usage. In the US and UK, Modafinil (Provigil) has been used to treat a number of disorders safely due to its characteristics of not causing addiction or drug dependency.
Apart from these effects, it has been found that Modafinil has antioxidative and neuroprotective effects. They can prevent cellular damage from inhibiting the free radicals. Thus, people taking Modafinil may get some added advantages as in the present-day lifestyle, our tissues are at greater risk of undergoing oxidative damage.
How should you take Modafinil.
Modafinil is an oral drug available as capsule shaped tablets (Provigil Oral Tab 100 mg/ 200 mg, Modalert 100 mg/ 200 mg), it is swallowed with a glass of water. They are uncoated tablets formulated for rapid absorption. For healthy adults, the most commonly administered dose is 200 mg once daily as a single dose in the morning, however doses more up to 400 mg has shown to be well tolerated. The doses can be sometimes divided into 100 mg in the morning and 100 mg in the evening. This is done to facilitate good nocturnal sleep. It is not to be used in children, infants and neonates.
The dosage and duration of your treatment with Modafinil is decided by your physician after she/he performs a thorough examination of your condition. Online stores maybe the best place to buy Modafinil. In most of the countries like the UK and US, Modafinil is a prescription only medicine. However, in some stores it may be available without prescription. In Australia, Modafinil is a schedule 4 prescription only drug. You can even avail an online prescription for Modafinil (Provigil/ Modalert 200 mg). Canada and Mexico do not classify Modafinil as controlled substance and is available Over the Counter. Before you buy Modafinil, check with your doctor or pharmacist or RNs to confirm that you are buying the right drug with the right dose. Always take Modafinil exactly as your doctor has told you. It is not illegal to buy Modafinil for therapeutic uses.
If you are suffering from hepatic dysfunction (liver diseases), Renal (kidney) diseases, or certain other medical conditions, the dosage of Modafinil should be reduced. In most cases, your doctor will reduce the dosage by 50 percentage i.e. Modafinil 100 mg once daily in the morning.
It should be noted that, consumption of Modafinil more than recommended doses, i.e. more than 200 mg PO daily every morning, you are less likely to have any added effects, this may in fact worsen your condition or make you feel sick and hence, overdose should be avoided.
In cases where you miss a dose, take the tablet as soon as you remember. If it is close to the time for the next dose, it is recommended to skip the missed dose. Continue your regular drug schedule from the next dose. NEVER double dose to compensate for the missed dose. Modafinil should not be taken before sleep as it will keep you awake throughout the night.
Modafinil 200 mg (Provigil/ Modalert 200 mg) is the safest recommended dosage for most individuals. If you happen to overdose yourself with Modafinil, you should visit your physician immediately to avoid any undesirable adverse events. No research has found any lethal effects of Modafinil overdose. People who taking Modafinil are advised to be well aware of any side effects associated with it and also to abstain themselves from drug abuse as taking more than the recommended dose is found to produce no additional benefit.
Modafinil may interact with certain drugs such as Antivirals, Abemaciclib, Acetaminophen, Amlodipine, certain antibiotics such as Amoxicillin and Clarythromycin, Amphetamine, Caffeine and others. These interactions may either aggravate or disseminate the action of those drugs, Modafinil or both. Individuals who are taking other medications should always consult a physician before taking Modafinil and discuss the safety issues prior.
Owing to its safety and other therapeutic benefits, Modafinil is now one of the most moving drugs in the global pharmaceutical market.